Gene set analysis using sufficient dimension reduction
نویسندگان
چکیده
منابع مشابه
Sufficient Dimension Reduction Summaries
Observational studies assessing causal or non-causal relationships between an explanatory measure and an outcome can be complicated by hosts of confounding measures. Large numbers of confounders can lead to several biases in conventional regression based estimation. Inference is more easily conducted if we reduce the number of confounders to a more manageable number. We discuss use of sufficien...
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Gene-set analysis aims to identify differentially expressed gene sets (pathways) by a phenotype in DNA microarray studies. We review here important methodological aspects of gene-set analysis and illustrate them with varying performance of several methods proposed in the literature. We emphasize the importance of distinguishing between 'self-contained' versus 'competitive' methods, following Go...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2016
ISSN: 1471-2105
DOI: 10.1186/s12859-016-0928-6